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KMID : 0354720070310060507
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Journal of Korean Diabetes Association
2007 Volume.31 No. 6 p.507 ~ p.516
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The Plasma Adiponectin Levels in Patients with Newly Diagnosed Type 2 Diabetes
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Lee Ihn-Suk
Lee Tae-Yong
Kim Yun-Jeung
Kim Young-Kun
Ku Bon-Jeong
Park Kang-Seo
Park Jae-Hyeong
Kim Jong-Im
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Abstract
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Background: Adiponectin is secreted from adipose tissue and plays an important role in the regulation of glycemia and insulin resistance. In this study, the relationship between adiponectin and the adiposity, body composition, insulin sensitivity, lipid profile were respectively examined in newly diagnosed type 2 diabetes.
Methods: Total 1993 were participated in the Korea Rural Genomic Cohort Study (Geumsan County). After a 12-hour overnight fast, all subjects underwent 75-g oral glucose tolerance test. 105 of those were studied as newly diagnosed type 2 diabetes. The body composition was analyzed by means of bioelectric impedance analysis and the insulin sensitivity was estimated by fasting insulin, HOMA-IR and QUICKI method, respectively.
Results: Adiponectin positively correlated with high-density lipoprotein cholesterol (r = 0.246, P < 0.05). Adiponectin inversely associated with waist circumference (r = - 0.408, P < 0.01), triglyceride (r = -0.274, P < 0.05), ferritin (r = -0.260, P < 0.05), visceral fat (r = -0.248, P < 0.05), high sensitivity C-reactive protein (r = -0.228, P < 0.05) and body mass index (r = -0.225, P < 0.05). In multiple linear regression, waist circumference and high-density lipoprotein cholesterol were analyzed as independent variables of serum adiponectin.
Conclusion: Adiponectin concentrations were closely related to waist circumference in newly diagnosed type 2 diabetes.
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KEYWORD
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Adiponectin, Diabetes Mellitus, Type 2, Insulin Resistance
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